Search results for "fusion [photon photon]"
showing 10 items of 724 documents
Advancements in DEMO WCLL breeding blanket design and integration
2017
Summary The water-cooled lithium–lead breeding blanket is a candidate option for the European Demonstration Power Plant (DEMO) nuclear fusion reactor. This breeding blanket concept relies on the liquid lithium–lead as breeder–multiplier, pressurized water as coolant, and EUROFER as structural material. The current design is based on DEMO 2015 specifications and represents the follow-up of the design developed in 2015. The single-module-segment approach is employed. This is constituted by a basic geometry repeated along the poloidal direction. The power is removed by means of radial–toroidal (i.e., horizontal) water cooling tubes in the breeding zone. The lithium–lead flows in a radial–poloi…
Validation of the group nuclear safety climate questionnaire.
2013
Abstract Introduction Group safety climate is a leading indicator of safety performance in high reliability organizations. Zohar and Luria (2005) developed a Group Safety Climate scale (ZGSC) and found it to have a single factor. Method The ZGSC scale was used as a basis in this study with the researchers rewording almost half of the items on this scale, changing the referents from the leader to the group, and trying to validate a two-factor scale. The sample was composed of 566 employees in 50 groups from a Spanish nuclear power plant. Item analysis, reliability, correlations, aggregation indexes and CFA were performed. Results Results revealed that the construct was shared by each unit, a…
Mock-up testing facilities and qualification strategy for EU ITER TBMs
2010
European test blanket modules (TBM) for both European blanket concepts, namely the Helium Cooled Lithium Lead (HCLL) and the Helium Cooled Pebble Bed (HCPB), and their auxiliary systems have been designed in the last years. This paper presents the experimental facilities available in Europe for the qualification tests of European TBMs. In particular, devices designed to analyze specific technological issues, for example corrosion under strong magnetic fields or tritium management and extraction, as well as large scale facility to perform integral tests are described. A preliminary overview on the qualification strategy is presented and discussed.
Avidin Is a Promising Tag for Fusion Proteins Produced in Baculovirus-Infected Insect Cells
1999
The baculovirus expression vector system (BEVS) has become one of the most versatile and powerful eukaryotic systems for recombinant protein expression. We have constructed a novel baculovirus transfer vector (pbacAVs+C) which allows for the efficient production, detection, and single-step purification of the desired molecule as a secretion-compatible avidin fusion protein in insect cells. It also enables fast construction of the baculoviruses by site-specific transposition in Escherichia coli. To demonstrate the power of this vector, we report here on the production of immunologically intact hevein, a major cysteine-rich latex allergen, as avidin fusion protein. Our results indicate that a…
Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants
1999
AbstractEndogenous, constitutive soluble epoxide hydrolase in mice 3T3 cells was localized via immunofluorescence microscopy exclusively in peroxisomes, whereas transiently expressed mouse soluble epoxide hydrolase (from clofibrate-treated liver) accumulated only in the cytosol of 3T3 and HeLa cells. When the C-terminal Ile of mouse soluble epoxide hydrolase was mutated to generate a prototypic putative type 1 PTS (-SKI to -SKL), the enzyme targeted to peroxisomes. The possibility that soluble epoxide hydrolase-SKI was sorted slowly to peroxiosmes from the cytosol was examined by stably expressing rat soluble epoxide hydrolase-SKI appended to the green fluorescent protein. Green fluorescent…
Expression of Active Streptolysin O in Escherichia coli as a Maltose-Binding-Protein-Streptolysin-O Fusion Protein. The N-Terminal 70 Amino Acids are…
1996
Streptolysin 0 (SLO) is the prototype of a family of cytolysins that consists of proteins which bind to cholesterol and form very large transmembrane pores. Structure/function studies on the pore-forming cytolysin SLO have been complicated by the proteolytic inactivation of a substantial portion of recombinant SLO (rSLO) expressed in Escherichia coli. To overcome this problem, translational fusions between the E. coli maltose-binding protein (MBP) gene and SLO were constructed, using the vectors pMAL-p2 and pMAL-c2. MBP-SLO fusion proteins were degraded if secreted into the E. coli periplasm, but intact, soluble MBP-SLO fusion proteins were produced at high levels in the cytoplasm. Active S…
AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS
2000
H-IL-6 is a hybrid protein constructed to contain IL-6 and its soluble receptor linked by a flexible peptide chain. Here we show that H-IL-6 strongly enhances proliferation of human CD34(+)cells in serum-free liquid culture, and that the majority of the cells generated belong to the erythroid lineage, being positive for the marker Glycophorin A. Conversely, H-IL-6 does not increase the number of myeloid, CD13-positive cells. Comparable effects are observed on progenitors from cord blood and adult peripheral blood. Therefore, H-IL-6 triggers an erythroid-inducing signal in haematopoietic progenitor cells, independently from erythropoietin (EPO).
Forward and backward diffusion approximations for haploid exchangeable population models
2001
Abstract The class of haploid population models with non-overlapping generations and fixed population size N is considered such that the family sizes ν1,…,νN within a generation are exchangeable random variables. A criterion for weak convergence in the Skorohod sense is established for a properly time- and space-scaled process counting the number of descendants forward in time. The generator A of the limit process X is constructed using the joint moments of the offspring variables ν1,…,νN. In particular, the Wright–Fisher diffusion with generator Af(x)= 1 2 x(1−x)f″(x) appears in the limit as the population size N tends to infinity if and only if the condition lim N→∞ E((ν 1 −1) 3 )/(N Var …
Distributed and proximity-constrained C-means for discrete coverage control
2018
In this paper we present a novel distributed coverage control framework for a network of mobile agents, in charge of covering a finite set of points of interest (PoI), such as people in danger, geographically dispersed equipment or environmental landmarks. The proposed algorithm is inspired by C-Means, an unsupervised learning algorithm originally proposed for non-exclusive clustering and for identification of cluster centroids from a set of observations. To cope with the agents' limited sensing range and avoid infeasible coverage solutions, traditional C-Means needs to be enhanced with proximity constraints, ensuring that each agent takes into account only neighboring PoIs. The proposed co…
An exploratory study of COVID-19 misinformation on Twitter.
2020
During the COVID-19 pandemic, social media has become a home ground for misinformation. To tackle this infodemic, scientific oversight, as well as a better understanding by practitioners in crisis management, is needed. We have conducted an exploratory study into the propagation, authors and content of misinformation on Twitter around the topic of COVID-19 in order to gain early insights. We have collected all tweets mentioned in the verdicts of fact-checked claims related to COVID-19 by over 92 professional fact-checking organisations between January and mid-July 2020 and share this corpus with the community. This resulted in 1 500 tweets relating to 1 274 false and 276 partially false cla…